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首页> 外文OA文献 >Suppression of Leukotriene B4 Generation by Ex-vivo Neutrophils Isolated from Asthma Patients on Dietary Supplementation with Gammalinolenic Acid-containing Borage Oil: Possible Implication in Asthma
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Suppression of Leukotriene B4 Generation by Ex-vivo Neutrophils Isolated from Asthma Patients on Dietary Supplementation with Gammalinolenic Acid-containing Borage Oil: Possible Implication in Asthma

机译：饮食中补充含γ亚麻酸的琉璃苣油对哮喘患者的离体中性粒细胞产生白三烯B4的抑制作用：对哮喘的可能影响

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Dietary gammalinolenic acid (GLA), a potent inhibitor of 5-lipoxygenase (5-LOX) and suppressor ofleukotriene B4 (LTB4), can attenuate the clinical course of rheumatoid arthritics, with negligible sideeffects. Since Zileuton, also an inhibitor of 5-LOX, attenuates asthma but with an undesirable sideeffect, we investigated whether dietary GLA would suppress biosynthesis of PMN-LTB4 isolated fromasthma patients and attenuate asthma. Twenty-four mild-moderate asthma patients (16–75 years) wererandomized to receive either 2.0 g daily GLA (borage oil) or corn oil (placebo) for 12 months. Blooddrawn at 3 months intervals was used to prepare sera for fatty acid analysis, PMNs for determiningphospholipid fatty acids and for LTB4 generation. Patients were monitored by daily asthma scores,pulmonary function, and exhaled NO. Ingestion of daily GLA (i) increased DGLA (GLA metabolite) inPMN-phospholipids; (ii) increased generation of PMN-15-HETrE (5-LOX metabolite of DGLA).Increased PMN-DGLA/15-HETrE paralleled the decreased PMN generation of proinflammatory LTB4.However, the suppression of PMN-LTB4 did not reveal statistically significant suppression of theasthma scores evaluated. Nonetheless, the study demonstrated dietary fatty acid modulation ofendogenous inflammatory mediators without side effects and thus warrant further explorations into theroles of GLA at higher doses, leukotrienes and asthma.
机译：饮食中的亚麻酸（GLA）是有效的5-脂氧合酶（5-LOX）抑制剂和白三烯B4（LTB4）的抑制剂，可减轻类风湿关节炎的临床病程，且副作用可忽略不计。由于Zileuton还是5-LOX的抑制剂，可减轻哮喘但具有不良副作用，因此我们研究了饮食GLA是否会抑制哮喘患者中分离出的PMN-LTB4的生物合成并减轻哮喘。 24名轻度-中度哮喘患者（16-75岁）被随机分配接受每日2.0 g GLA（琉璃苣油）或玉米油（安慰剂）治疗12个月。每隔3个月抽血用于制备血清用于脂肪酸分析，PMN用于确定磷脂脂肪酸和LTB4生成。通过每日哮喘评分，肺功能和呼出NO监测患者。每天摄入GLA（i）PMN磷脂中的DGLA（GLA代谢产物）增加； （ii）PMN-15-HETrE（DGLA的5-LOX代谢产物）的生成增加.PMN-DGLA / 15-HETrE的增加与促炎性LTB4的PMN生成减少平行，但是对PMN-LTB4的抑制没有统计学意义。评估哮喘分数的抑制作用。尽管如此，该研究表明饮食中脂肪酸对内源性炎症介质的调节无副作用，因此有必要进一步研究高剂量GLA的酚类，白三烯和哮喘。

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